RELA

RELA
Наявні структури
PDB	Пошук ортологів: PDBe RCSB
Список кодів PDB
	4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22
Ідентифікатори
Символи	RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
Зовнішні ІД	OMIM: 164014 MGI: 103290 HomoloGene: 32064 GeneCards: RELA
Онтологія гена
Молекулярна функція	• protein N-terminus binding; • ankyrin repeat binding; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • histone deacetylase binding; • enzyme binding; • phosphate ion binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • protein homodimerization activity; • chromatin binding; • NF-kappaB binding; • GO:0001948, GO:0016582 protein binding; • protein kinase binding; • DNA binding; • sequence-specific DNA binding; • actinin binding; • protein heterodimerization activity; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • chromatin DNA binding; • ubiquitin protein ligase binding; • GO:0000983 RNA polymerase II general transcription initiation factor activity; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • identical protein binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • GO:0032403 protein-containing complex binding;
Клітинна компонента	• цитоплазма; • гіалоплазма; • I-kappaB/NF-kappaB complex; • transcription regulator complex; • NF-kappaB complex; • нуклеоплазма; • клітинне ядро; • ядерце; • NF-kappaB p50/p65 complex; • GO:0009327 protein-containing complex; • синапс; • glutamatergic synapse;
Біологічний процес	• response to amino acid; • response to interleukin-1; • cellular response to interleukin-6; • response to progesterone; • response to organic substance; • Fc-epsilon receptor signaling pathway; • GO:1903105 negative regulation of insulin receptor signaling pathway; • defense response to virus; • positive regulation of chondrocyte differentiation; • animal organ morphogenesis; • response to muscle stretch; • response to cytokine; • GO:1903363 negative regulation of protein catabolic process; • cytokine-mediated signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway; • response to mechanical stimulus; • response to muramyl dipeptide; • stimulatory C-type lectin receptor signaling pathway; • transcription, DNA-templated; • response to insulin; • negative regulation of NIK/NF-kappaB signaling; • nucleotide-binding oligomerization domain containing 2 signaling pathway; • membrane protein intracellular domain proteolysis; • inflammatory response; • GO:0022415 viral process; • response to cobalamin; • hair follicle development; • positive regulation of miRNA metabolic process; • acetaldehyde metabolic process; • cellular response to hepatocyte growth factor stimulus; • cellular response to nicotine; • negative regulation of apoptotic process; • cellular defense response; • response to morphine; • response to lipopolysaccharide; • cellular response to interleukin-1; • response to inorganic substance; • regulation of inflammatory response; • response to cAMP; • GO:0045996 negative regulation of transcription, DNA-templated; • response to hydrogen peroxide; • positive regulation of Schwann cell differentiation; • defense response; • response to bacterium; • GO:1904578 response to organic cyclic compound; • GO:0010260 старіння людини; • positive regulation of cell population proliferation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • liver development; • response to UV-B; • T cell receptor signaling pathway; • cellular response to lipopolysaccharide; • positive regulation of type I interferon production; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • cellular response to hydrogen peroxide; • GO:0009373 regulation of transcription, DNA-templated; • tumor necrosis factor-mediated signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of T cell receptor signaling pathway; • positive regulation of NF-kappaB transcription factor activity; • cellular response to peptidoglycan; • cellular response to tumor necrosis factor; • regulation of NIK/NF-kappaB signaling; • positive regulation of NIK/NF-kappaB signaling; • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; • positive regulation of pri-miRNA transcription by RNA polymerase II; • regulation of DNA-templated transcription in response to stress; • cellular response to lipoteichoic acid; • GO:1901227 negative regulation of transcription by RNA polymerase II; • negative regulation of protein sumoylation; • pri-miRNA transcription by RNA polymerase II; • cellular response to angiotensin; • interleukin-1-mediated signaling pathway; • cellular response to vascular endothelial growth factor stimulus; • negative regulation of pri-miRNA transcription by RNA polymerase II; • postsynapse to nucleus signaling pathway; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • I-kappaB kinase/NF-kappaB signaling; • NIK/NF-kappaB signaling; • positive regulation of leukocyte adhesion to vascular endothelial cell;
	Джерела:Amigo / QuickGO
Шаблон експресії
	; ;
	Більше даних
Ортологи
	5970
	19697
	ENSG00000173039
	ENSMUSG00000024927
	Q04206
	Q04207
	NM_001145138; NM_001243984; NM_001243985; NM_021975
	NM_009045; NM_001365067
	NP_001138610; NP_001230913; NP_001230914; NP_068810
	NP_033071; NP_001351996
	Вікідані
Див./Ред. для людей	Див./Ред. для мишей

RELA (англ. RELA proto-oncogene, NF-kB subunit) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.^[3] Довжина поліпептидного ланцюга білка становить 551 амінокислот, а молекулярна маса — 60 219^[4].

Послідовність амінокислот

10	20	30	40	50
MDELFPLIFP	AEPAQASGPY	VEIIEQPKQR	GMRFRYKCEG	RSAGSIPGER
STDTTKTHPT	IKINGYTGPG	TVRISLVTKD	PPHRPHPHEL	VGKDCRDGFY
EAELCPDRCI	HSFQNLGIQC	VKKRDLEQAI	SQRIQTNNNP	FQVPIEEQRG
DYDLNAVRLC	FQVTVRDPSG	RPLRLPPVLS	HPIFDNRAPN	TAELKICRVN
RNSGSCLGGD	EIFLLCDKVQ	KEDIEVYFTG	PGWEARGSFS	QADVHRQVAI
VFRTPPYADP	SLQAPVRVSM	QLRRPSDREL	SEPMEFQYLP	DTDDRHRIEE
KRKRTYETFK	SIMKKSPFSG	PTDPRPPPRR	IAVPSRSSAS	VPKPAPQPYP
FTSSLSTINY	DEFPTMVFPS	GQISQASALA	PAPPQVLPQA	PAPAPAPAMV
SALAQAPAPV	PVLAPGPPQA	VAPPAPKPTQ	AGEGTLSEAL	LQLQFDDEDL
GALLGNSTDP	AVFTDLASVD	NSEFQQLLNQ	GIPVAPHTTE	PMLMEYPEAI
TRLVTGAQRP	PDPAPAPLGA	PGLPNGLLSG	DEDFSSIADM	DFSALLSQIS
S

A: Аланін
 C: Цистеїн
 D: Аспарагінова кислота
 E: Глутамінова кислота
 F: Фенілаланін
 G: Гліцин
 H: Гістидин
 I: Ізолейцин
 K: Лізин
 L: Лейцин
 M: Метіонін
 N: Аспарагін
 P: Пролін
 Q: Глутамін
 R: Аргінін
 S: Серин
 T: Треонін
 V: Валін
 W: Триптофан
 
 Y: Тирозин

Кодований геном білок за функціями належить до активаторів, фосфопротеїнів. Задіяний у таких біологічних процесах, як взаємодія хазяїн-вірус, транскрипція, регуляція транскрипції, ацетилювання, альтернативний сплайсинг. Білок має сайт для зв'язування з ДНК. Локалізований у цитоплазмі, ядрі.

Література

Deloukas P., van Loon A.P.G.M. (1993). Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing. Hum. Mol. Genet. 2: 1895—1900. PMID 8281153 DOI:10.1093/hmg/2.11.1895
Lyle R., Valleley E.M., Sharpe P.T., Hewitt J.E. (1994). An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B. Gene. 138: 265—266. PMID 7907305 DOI:10.1016/0378-1119(94)90823-0
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14: 2121—2127. 2004. PMID 15489334 DOI:10.1101/gr.2596504
Ruben S.M., Narayanan R., Klement J.F., Chen C.-H., Rosen C.A. (1992). Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative. Mol. Cell. Biol. 12: 444—454. PMID 1732726 DOI:10.1128/MCB.12.2.444
Ganchi P.A., Sun S.C., Greene W.C., Ballard D.W. (1992). I kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA binding. Mol. Biol. Cell. 3: 1339—1352. PMID 1493333 DOI:10.1091/mbc.3.12.1339
Li Z., Nabel G.J. (1997). A new member of the IkappaB protein family, IkappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription. Mol. Cell. Biol. 17: 6184—6190. PMID 9315679 DOI:10.1128/MCB.17.10.6184