SLC22A8
SLC22A8 (Solute carrier family 22 member 8) هوَ بروتين يُشَفر بواسطة جين SLC22A8 في الإنسان.[1][2][3]
الوظيفة
[عدل]![[أيقونة]](%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
[عدل] | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
[عدل]- ^ EntrezGene 9376
- ^ VanWert AL، Gionfriddo MR، Sweet DH (2009). "Organic anion transporters: Discovery, pharmacology, regulation and roles in pathophysiology". Biopharmaceutics & Drug Disposition. ج. 31: 1–71. DOI:10.1002/bdd.693. PMID:19953504.
- ^ Race JE، Grassl SM، Williams WJ، Holtzman EJ (1999). "Molecular Cloning and Characterization of Two Novel Human Renal Organic Anion Transporters (hOAT1 and hOAT3)". Biochemical and Biophysical Research Communications. ج. 255 ع. 2: 508–14. DOI:10.1006/bbrc.1998.9978. PMID:10049739.
قراءة متعمقة
[عدل]- Babu E، Takeda M، Narikawa S، Kobayashi Y، Yamamoto T، Cha SH، Sekine T، Sakthisekaran D، Endou H (2002). "Human Organic Anion Transporters Mediate the Transport of Tetracycline". The Japanese Journal of Pharmacology. ج. 88 ع. 1: 69–76. DOI:10.1254/jjp.88.69. PMID:11855680.
- Motohashi H، Sakurai Y، Saito H، Masuda S، Urakami Y، Goto M، Fukatsu A، Ogawa O، Inui K (2002). "Gene expression levels and immunolocalization of organic ion transporters in the human kidney". Journal of the American Society of Nephrology. ج. 13 ع. 4: 866–74. PMID:11912245.
- Nishizato Y، Ieiri I، Suzuki H، Kimura M، Kawabata K، Hirota T، Takane H، Irie S، وآخرون (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics". Clinical Pharmacology & Therapeutics. ج. 73 ع. 6: 554–65. DOI:10.1016/S0009-9236(03)00060-2. PMID:12811365.
- Bakhiya A، Bahn A، Burckhardt G، Wolff N (2003). "Human Organic Anion Transporter 3 (hOAT3) can Operate as an Exchanger and Mediate Secretory Urate Flux". Cellular Physiology and Biochemistry. ج. 13 ع. 5: 249–56. DOI:10.1159/000074539. PMID:14586168.
- Sakurai Y، Motohashi H، Ueo H، Masuda S، Saito H، Okuda M، Mori N، Matsuura M، وآخرون (2004). "Expression Levels of Renal Organic Anion Transporters (OATs) and Their Correlation with Anionic Drug Excretion in Patients with Renal Diseases". Pharmaceutical Research. ج. 21 ع. 1: 61–7. DOI:10.1023/B:PHAM.0000012153.71993.cb. PMID:14984259.
- Srimaroeng C، Chatsudthipong V، Aslamkhan AG، Pritchard JB (2004). "Transport of the Natural Sweetener Stevioside and Its Aglycone Steviol by Human Organic Anion Transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)". Journal of Pharmacology and Experimental Therapeutics. ج. 313 ع. 2: 621–8. DOI:10.1124/jpet.104.080366. PMID:15644426.
- Tahara H، Shono M، Kusuhara H، Kinoshita H، Fuse E، Takadate A، Otagiri M، Sugiyama Y (2005). "Molecular Cloning and Functional Analyses of OAT1 and OAT3 from Cynomolgus Monkey Kidney". Pharmaceutical Research. ج. 22 ع. 4: 647–60. DOI:10.1007/s11095-005-2503-0. PMID:15846473.
- Erdman AR، Mangravite LM، Urban TJ، Lagpacan LL، Castro RA، de la Cruz M، Chan W، Huang CC، وآخرون (2005). "The human organic anion transporter 3 (OAT3; SLC22A8): Genetic variation and functional genomics". AJP: Renal Physiology. ج. 290 ع. 4: F905–12. DOI:10.1152/ajprenal.00272.2005. PMID:16291576.
- Tahara H، Kusuhara H، Maeda K، Koepsell H، Fuse E، Sugiyama Y (2006). "Inhibition of Oat3-Mediated Renal Uptake As a Mechanism for Drug-Drug Interaction Between Fexofenadine and Probenecid". Drug Metabolism and Disposition. ج. 34 ع. 5: 743–7. DOI:10.1124/dmd.105.008375. PMID:16455804.
- Bhatnagar V، Xu G، Hamilton BA، Truong DM، Eraly SA، Wu W، Nigam SK (2006). "Analyses of 5′ regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3)". Journal of Human Genetics. ج. 51 ع. 6: 575–80. DOI:10.1007/s10038-006-0398-1. PMID:16648942.
- Kikuchi R، Kusuhara H، Hattori N، Shiota K، Kim I، Gonzalez FJ، Sugiyama Y (2006). "Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1 /beta and DNA Methylation". Molecular Pharmacology. ج. 70 ع. 3: 887–96. DOI:10.1124/mol.106.025494. PMID:16793932.
- Mizuno N، Takahashi T، Iwase Y، Kusuhara H، Niwa T، Sugiyama Y (2007). "Human Organic Anion Transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) Transport Edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and Its Sulfate Conjugate". Drug Metabolism and Disposition. ج. 35 ع. 8: 1429–34. DOI:10.1124/dmd.106.013912. PMID:17502342.
- Matsumoto S، Yoshida K، Ishiguro N، Maeda T، Tamai I (2007). "Involvement of Rat and Human Organic Anion Transporter 3 in the Renal Tubular Secretion of Topotecan [(S)-9-Dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]". Journal of Pharmacology and Experimental Therapeutics. ج. 322 ع. 3: 1246–52. DOI:10.1124/jpet.107.123323. PMID:17556638.
- Nozaki Y، Kusuhara H، Kondo T، Iwaki M، Shiroyanagi Y، Nakayama H، Horita S، Nakazawa H، وآخرون (2007). "Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices". Journal of Pharmacology and Experimental Therapeutics. ج. 322 ع. 3: 1162–70. DOI:10.1124/jpet.107.121491. PMID:17578901.
- Vanwert AL، Bailey RM، Sweet DH (2007). "Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G". AJP: Renal Physiology. ج. 293 ع. 4: F1332–41. DOI:10.1152/ajprenal.00319.2007. PMC:2820253. PMID:17686950.
- VanWert AL، Sweet DH (2007). "Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates". Pharmaceutical Research. ج. 25 ع. 2: 453–62. DOI:10.1007/s11095-007-9407-0. PMC:2820254. PMID:17660957.
- Windass AS، Lowes S، Wang Y، Brown CD (2007). "The Contribution of Organic Anion Transporters OAT1 and OAT3 to the Renal Uptake of Rosuvastatin". Journal of Pharmacology and Experimental Therapeutics. ج. 322 ع. 3: 1221–7. DOI:10.1124/jpet.107.125831. PMID:17585018.
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